丝素
自愈水凝胶
生物相容性
体内
聚乙烯吡咯烷酮
材料科学
生物医学工程
药物输送
聚合
MTT法
化学
丝绸
聚合物
高分子化学
纳米技术
体外
复合材料
生物化学
医学
冶金
生物技术
生物
作者
Xiaoyan Ren,Bing Teng,Yanhua Jiang,Lili Guo,Hong Ma
标识
DOI:10.1016/j.jddst.2022.103810
摘要
Investigations may quickly and easily convert a sol-gel into a gel-like substance-using photocurable hydrogel, which has several potential uses in biomedical research. N-Vinyl-2-pyrrolidone (NVP) monomer has been converted into Polyvinylpyrrole (PVP) and interacting matrix with silk fibroin macromolecule hydrogel by photoinitiated polymerization in this study. MTT experiment and microscopic inspections proved the PVP/SF hydrogel's biocompatibility with L929 fibroblast cell lines (96% cell survival and growth compatibility). This hydrogel's release pattern is unique from other hydrogels because of its delayed and low cumulative release. Mice models were used to show treated materials' anaesthetic and toxicological effects. Additionally, PVP/[email protected] hydrogels dramatically suppress in vivo tumour development in mouse models and efficiently minimize their in vivo toxicity. In vitro and in vivo testing revealed that encapsulating LDC in PVP/SF hydrogels improved the drug's anaesthetic activity while extending its duration. Experimental research involving the controlled release of local anaesthetics might make excellent use of this new approach.
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