冬虫夏草
当归
氨基酸
虫草素
化学
生物化学
生物
环磷酰胺
传统医学
植物
化疗
医学
替代医学
病理
中医药
遗传学
作者
Zhang Yu,Jie Liu,Yan Wang,Cheng‐Peng Sun,Wenjia Li,Jian-Jian Qiu,Yujie Qiao,Fan Wu,Xiaokui Huo,Yue An,Baojing Zhang,Shuang‐Cheng Ma,Jian Zheng,Xiaochi Ma
标识
DOI:10.1080/14786419.2022.2043307
摘要
The material basis of Cordyceps sinensis (Berk.) Sacc has not yet been well understood and natural C. sinensis resources are very rare. The present study aimed to clarify the substance basis and compare the protective effect of natural and artificially-cultivated C. sinensis against cyclophosphamide (CTX)-induced myelosuppression. Both natural and artificially-cultivated C. sinensis effectively improved CTX-induced decrease of peripheral blood counts and hemopoietic growth factors, pathological changes, and apoptosis of bone marrow. Importantly, artificially-cultivated C. sinensis showed similar capacity compared with natural C. sinensis. Uridine (1), adenosine (2), L-pyroglutamic acid (3), lysinonorleucine (4), 1,3,5-trimethoxybenzene (5), D-mannitol (6), L-pyroglutamic acid methyl ester (7), tryptophan (8), and phenylalanine (9) were isolated from bioactivity-guided fraction and identified to attenuate CTX-induced myelosuppression in mice. In conclusions, nucleosides and amino acids represented the effective chemical components in C. sinensis. Artificial cultivation can be used as an effective substitute for natural C. sinensis.
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