Molecular glues targeting protein degradation pathways for drug discovery

药店 印度 医学 医院药房 中国 传统医学 图书馆学 家庭医学 政治学 计算机科学 法学
作者
Changyu Ren,Xiaohong Tracey Gan,Houfeng Zhou,Jinqi Li,Jifa Zhang
出处
期刊:Future Medicinal Chemistry [Newlands Press Ltd]
卷期号:14 (3): 135-137 被引量:2
标识
DOI:10.4155/fmc-2021-0229
摘要

Future Medicinal ChemistryVol. 14, No. 3 EditorialMolecular glues targeting protein degradation pathways for drug discoveryChangyu Ren, Xiaohong Gan, Houfeng Zhou, Jinqi Li & Jifa ZhangChangyu RenDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Xiaohong GanDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Houfeng ZhouDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Jinqi Li*Author for correspondence: E-mail Address: lijinqi2002@126.comDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, ChinaSearch for more papers by this author & Jifa Zhang **Author for correspondence: E-mail Address: zjf298257@163.comhttps://orcid.org/0000-0001-8618-9200Department of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaState Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, ChinaSearch for more papers by this authorPublished Online:15 Nov 2021https://doi.org/10.4155/fmc-2021-0229AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: degraded proteinsdrug discoverymolecular gluesnon-drug targetsReferences1. Platis D, Sotriffer CA, Clonis Y et al. Lock-and-key motif as a concept for designing affinity adsorbents for protein purification. J. Chromatogr. A 1128(1–2), 138–151 (2006).Crossref, Medline, CAS, Google Scholar2. Liu CL, Zhang R, Zhang WZ et al. “Dual-key-and-lock” ruthenium complex probe for lysosomal formaldehyde in cancer cells and tumors. J. Am. Chem. Soc. 141(21), 8462–8472 (2019).Crossref, Medline, CAS, Google Scholar3. Pei JP, Wang G, Feng L et al. Targeting lysosomal degradation pathways: new strategies and techniques for drug discovery. J. Med. Chem. 64(7), 3493–3507 (2021).Crossref, Medline, CAS, Google Scholar4. Chamberlain PP, Hamann LG. Development of targeted protein degradation therapeutics. Nat. Chem. Biol. 15(10), 937–944 (2019).Crossref, Medline, CAS, Google Scholar5. Wang Y, Jiang X, Feng F et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm. Sin. B 10(2), 207–238 (2020).Crossref, Medline, CAS, Google Scholar6. Zhang JF, Ouyang L. Proteolysis-targeting chimeras in breast cancer therapy. Future. Med. Chem. 12(24), 2175–2177 (2020).Link, CAS, Google Scholar7. Schreiber SL. The rise of molecular glues. Cell 184, 3–9 (2021).Crossref, Medline, CAS, Google Scholar8. Baek K, Schulman BA. Molecular glue concept solidifies. Nat. Chem. Biol. 16, 2–3 (2020).Crossref, Medline, CAS, Google Scholar9. Tian C, Burgess K. PROTAC compatibilities, degrading cell-surface receptors, and the sticky problem of finding a molecular glue. ChemMedChem 16(2), 316–318 (2021).Crossref, Medline, CAS, Google Scholar10. Chamberlain PP, Cathers BE. Cereblon modulators: low molecular weight inducers of protein degradation. Drug Discov. Today Technol. 31, 29–34 (2019).Crossref, Medline, Google Scholar11. Matyskiela ME, Lu G, Ito T et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature 535, 252–257 (2016).Crossref, Medline, CAS, Google Scholar12. Słabicki M, Kozicka Z, Petzold G et al. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature 585(7824), 293–297 (2020).Crossref, Medline, CAS, Google Scholar13. Isobe Y, Okumura M, McGregor ML et al. Manumycin polyketides act as molecular glues between UBR7 and P53. Nat. Chem. Biol. 16(11), 1189–1198 (2020).Crossref, Medline, CAS, Google Scholar14. Yang Y, Sun Y, Wang J et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature 575, 203–209 (2019).Crossref, Medline, Google Scholar15. Lin X, Xiang H, Luo G. Targeting estrogen receptor alpha for degradation with PROTACs: a promising approach to overcome endocrine resistance. Eur. J. Med. Chem. 206, 112689 (2020).Crossref, Medline, CAS, Google Scholar16. Maniaci C, Ciulli A. Bifunctional chemical probes inducing protein–protein interactions. Curr. Opin. Chem. Biol. 52, 145–156 (2019).Crossref, Medline, CAS, Google Scholar17. Dong GQ, Ding Y, He SP. Molecular glues for targeted protein degradation: from serendipity to rational discovery. J. Med. Chem. 64(15), 10606–10620 (2021).Crossref, Medline, CAS, Google Scholar18. Zou Y, Ma D, Wang Y. The PROTAC technology in drug development. Cell Biochem. Funct. 37, 21–30 (2019).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 14, No. 3 Follow us on social media for the latest updates Metrics Downloaded 237 times History Received 10 August 2021 Accepted 27 October 2021 Published online 15 November 2021 Published in print February 2022 Information© 2021 Newlands PressKeywordsdegraded proteinsdrug discoverymolecular gluesnon-drug targetsFinancial & competing interests disclosureThe authors thank the National Natural Science Foundation of China (81903502), China Postdoctoral Science Foundation (2020M673268), Health Commission of Sichuan Province (20PJ002) and the Xinglin Foundation of Chengdu University of TCM (YYZX2021043). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
愉快树叶完成签到,获得积分10
2秒前
4秒前
充电宝应助斐嘿嘿采纳,获得10
8秒前
Uncle发布了新的文献求助10
9秒前
gjww应助晕晕采纳,获得10
9秒前
9秒前
10秒前
10秒前
其实发布了新的文献求助10
12秒前
龚盈盈完成签到,获得积分10
12秒前
mzhou发布了新的文献求助10
13秒前
田様应助Dongyu采纳,获得10
14秒前
零度发布了新的文献求助10
15秒前
RNA裂解酶发布了新的文献求助10
15秒前
雪白的笑槐完成签到,获得积分10
18秒前
19秒前
秋雪瑶应助柳子采纳,获得10
21秒前
科研通AI2S应助英勇的铸海采纳,获得10
22秒前
小鹏哥发布了新的文献求助10
25秒前
零度完成签到 ,获得积分10
25秒前
25秒前
26秒前
小二郎应助蜂鸟5156采纳,获得10
27秒前
wpl发布了新的文献求助10
27秒前
杨晓赞完成签到,获得积分10
29秒前
30秒前
spiritpope发布了新的文献求助10
30秒前
小鹏哥完成签到,获得积分10
31秒前
Dongyu发布了新的文献求助10
32秒前
32秒前
33秒前
benben应助ddl去暑采纳,获得10
33秒前
33秒前
打打应助FORWORD采纳,获得10
33秒前
marigold完成签到 ,获得积分10
35秒前
柳子发布了新的文献求助10
36秒前
37秒前
顾矜应助瘦瘦的胖彬采纳,获得10
40秒前
40秒前
40秒前
高分求助中
Heun’s Differential Equations 600
《Fundamentals of Power Supply Design》Robert A. Mammano 510
High Wire: How China Regulates Big Tech and Governs Its Economy 260
lingnan science journal vol. 16 250
The philosophy of sports medicine care: an historical review 250
A posteriori勾配制限手法「ポストリミタ」と界面捕獲法THINCを組み合わせた連続・不連続流れを高解像するMUSCLタイプの解法 210
Hybrid moth-flame optimisation algorithm with differential evolution for visual object tracking 200
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2251638
求助须知:如何正确求助?哪些是违规求助? 1900579
关于积分的说明 4743580
捐赠科研通 1690188
什么是DOI,文献DOI怎么找? 856910
版权声明 545565
科研通“疑难数据库(出版商)”最低求助积分说明 453854