成骨细胞
骨钙素
碱性磷酸酶
细胞生物学
化学
分泌物
骨量减少
内分泌学
基因表达
刺激(心理学)
内科学
生物
基因
生物化学
骨质疏松症
骨矿物
体外
医学
酶
心理学
心理治疗师
作者
Bing Wang,Shu Zhang,Xing-yu Wu
出处
期刊:Space medicine & medical engineering
日期:2003-06-01
卷期号:16 (3): 227-30
被引量:3
摘要
Skeleton system may adapt to multiform mechanical stimulus including gravity so as to modulate the balance between bone formation and absorption. Osteopenia under microgravity is mainly due to decrease of bone formation which relates closely to the low level of osteoblast activity. The proliferation and adhesive ability of osteoblast are reduced. The cells also express less messenger and protein of the differentiation and maturation-related substances, such as alkaline phosphatase, osteocalcin and type I collagen. The secretion of many growth factors is decreased and osteoblast responses less to them. It still remains unknown why the osteoblast is disfunctioned under microgravity. A hypothesis suggests the cellular shape changes may be the answer.
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