虫草素
幽门螺杆菌
免疫系统
胃炎
人口
生物
流式细胞术
微生物学
免疫学
作者
Wenjie Kong,Weidong Liu,Man Wang,Wenjia Hui,Yan Feng,Jiajie Lu,Buya Miranbieke,Huan Liu,Feng Gao
出处
期刊:Pathogens and Disease
[Oxford University Press]
日期:2022-01-01
标识
DOI:10.1093/femspd/ftac005
摘要
Helicobacter pylori is one of the dominant members of gastric microbiota associated with gastritis. Chronic H. pylori colonization may yield detrimental consequences, including mucosal layer atrophy, gastritis, and gastric cancer. The traditional antibiotic treatment might result in antibiotic resistance. To overcome this obstacle, this study aims to investigate the potential antibacterial and anti-inflammatory effects of cordycepin on mice infected with H. pylori. A mouse model of H. pylori infection was established. The expression levels of target genes were evaluated by qRT-PCR, western blotting, or ELISA. The infiltrated Th17 cell population was determined by flow cytometry analysis. Our results demonstrated that the administration of cordycepin exhibited up to 3-fold antibacterial effect against H. pyloriin vivo. Cordycepin treatment resulted in around 50% inflammatory cytokine production (e.g. IL-6 and IL-1β) and about 60% immune cell infiltration (e.g. Th17 cells) when compared to vehicle control group. Thus, we confirmed that cordycepin conferred antibacterial and anti-inflammatory effects on H. pylori-infected mice. Cordycepin may serve as a potential candidate for developing a therapeutic regimen for H. pylori-induced gastritis.
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