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Bacteriotherapy with Lactobacillus reuteri in rotavirus gastroenteritis

罗伊乳杆菌 腹泻 安慰剂 轮状病毒 医学 胃肠病学 益生菌 内科学 微生物学 细菌 生物 遗传学 替代医学 病理
作者
Aino-Vieno Shornikova,Ivàn A. Casas,Hannu Mykkänen,Eeva Salo,Timo Vesikari
出处
期刊:Pediatric Infectious Disease Journal [Ovid Technologies (Wolters Kluwer)]
卷期号:16 (12): 1103-1107 被引量:290
标识
DOI:10.1097/00006454-199712000-00002
摘要

Background. Certain lactic acid bacteria may accelerate recovery from acute diarrhea. Lactobacillus reuteri is a commonly occurring Lactobacillus species with therapeutic potential in diarrhea. Design. Prospective, randomized, placebo-controlled trial in two hospitals. Methods. Children between 6 and 36 months of age admitted for rotavirus-associated diarrhea were randomized into three groups to receive either 1010 or 107 colony-forming units (cfu) of L. reuteri or a matching placebo once a day for up to 5 days. Results. The main effect of L. reuteri was on the duration of watery diarrhea. The mean (±SD) duration of watery diarrhea after initiation of treatment was 2.5 (1.5) days in the placebo group (n = 25) vs. 1.9 (0.9) days in the small dosage (n = 20) and 1.5 (1.1) days in the large dosage (n = 21) L. reuteri recipients (P = 0.01). By the second day of treatment watery diarrhea persisted in 80% of the placebo, 70% of the small dosage and 48% of the large dosage L. reuteri recipients (P = 0.04, large dosage vs. placebo). Stool cultures for lactobacilli confirmed that administration of L. reuteri resulted in good colonization of the GI tract. The mean (±SD) of total Lactobacillus count 2 days after treatment initiation was 2.8 (1.6) log 10 cfu/g in the placebo group, 4.5 (2.0) log 10 cfu/g in the small dosage L. reuteri group and 6.1 (1.2) log 10 cfu/g in the large dosage L. reuteri group (P = 0.0004). Conclusions. L. reuteri effectively colonized the gastrointestinal tract after administration and significantly shortened the duration of watery diarrhea associated with rotavirus. There was a correlation between the dosage of L. reuteri and the clinical effect.
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