粘膜免疫
免疫记忆
免疫
医学
CCL18型
免疫系统
生物
免疫学
炎症
先天性淋巴细胞
表观遗传学
固有免疫
先天免疫系统
获得性免疫系统
疾病
体液免疫
细胞免疫
基因
遗传学
作者
Dou Yu,Jiaqi Zhang,Shuo Wang
出处
期刊:Wiley Interdisciplinary Reviews: Systems Biology and Medicine
[Wiley]
日期:2021-10-27
卷期号:14 (2)
被引量:3
摘要
Immune memory is well known as a signature of the adaptive immune system. Recently, enhanced responses to subsequent triggers are also observed in innate immune system, termed trained immunity (TI). Awakening of innate immune memory is required for host defense, such as anti-pathogen and anti-tumor responses. However, hyper-reactivation of trained innate immune cells also gives rise to undesirable inflammation. Mucosa immune system serves as the first defense line against pathogens. Trained immunity of mucosal immune system is tightly associated with the outcomes of mucosal diseases. In this review, we discuss the role of trained immunity in mucosal-associated diseases and the underlying mechanisms. We summarize the metabolic and epigenetic changes of trained immune cells and highlight their potential in clinical treatment. This article is categorized under: Infectious Diseases > Molecular and Cellular Physiology.
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