医学
糖尿病
置信区间
内科学
空腹血糖值
空腹血糖受损
队列
2型糖尿病
队列研究
内分泌学
糖耐量受损
胰岛素抵抗
作者
Yi Zhang,Tiantian Li,Runmei Ma,Zhaoxue Yin,Jiaonan Wang,Mike Z. He,Dandan Xu,Xiang Gao,Qing Wang,Virginia B. Kraus,Yuebin Lv,Yiren Zhong,Patrick L. Kinney,Xiaoming Shi
标识
DOI:10.1016/j.scitotenv.2020.137191
摘要
Fasting blood glucose level is the primary indicator for the diagnosis of diabetes. We aim to conduct a longitudinal study on the association between long-term fine particulate matter (PM2.5) exposure and fasting blood glucose concentrations. We recruited and followed up 1449 participants older than 65 years of age in 2009, 2012, 2014, and 2017 in eight counties in China. Fasting blood glucose was repeatedly measured 3697 times in total among these participants. Data on annual ground-level PM2.5 concentrations with a 0.01° spatial resolution from 2005 to 2016 were used to assess exposures. An increase of 10 μg/m3 in 3-year average exposure to PM2.5 was associated with an increase of 0.146 mmol/L (95% confidence interval [CI]: 0.045, 0.248) in fasting blood glucose in all participants. The association was more pronounced among the subgroup with diabetes compared to the subgroup without diabetes (P < .05). In conclusion, Long-term PM2.5 exposure was associated with an increase in fasting blood glucose levels among elderly people. Elderly individuals with diabetes are particularly vulnerable to high level exposures of PM2.5. SUMMARY: Long-term PM2.5 exposure was associated with an increase in fasting blood glucose levels among elderly people. Elderly individuals with diabetes are particularly vulnerable to high level exposures of PM2.5.
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