细胞生物学
心理压抑
表观遗传学
重编程
细胞
癌症研究
细胞分化
疾病
基因
作者
Denes Hnisz,Brian J. Abraham,Tong Ihn Lee,Ashley Lau,Violaine Saint-André,Alla A. Sigova,Heather A. Hoke,Richard A. Young
出处
期刊:Cell
[Elsevier]
日期:2013-11-07
卷期号:155 (4): 934-947
被引量:2172
标识
DOI:10.1016/j.cell.2013.09.053
摘要
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology would be afforded by knowing the constellation of factors that constitute these domains and by identifying super-enhancers across the spectrum of human cell types. We describe here the population of transcription factors, cofactors, chromatin regulators, and transcription apparatus occupying super-enhancers in embryonic stem cells and evidence that super-enhancers are highly transcribed. We produce a catalog of super-enhancers in a broad range of human cell types and find that super-enhancers associate with genes that control and define the biology of these cells. Interestingly, disease-associated variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, we find that cancer cells generate super-enhancers at oncogenes and other genes important in tumor pathogenesis. Thus, super-enhancers play key roles in human cell identity in health and in disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI