产热
褐色脂肪组织
内分泌学
内科学
肌动蛋白
FNDC5
FGF21型
白色脂肪组织
脂肪组织
脂肪因子
脂肪细胞
生物
产热素
瘦素
肥胖
医学
骨骼肌
细胞生物学
受体
成纤维细胞生长因子
纤维连接蛋白
细胞外基质
作者
Paul Lee,Joyce D. Linderman,Sarah Smith,Robert J. Brychta,Juan Wang,Christopher Idelson,Rachel M. Perron,C. Werner,Giao Q. Phan,Udai S. Kammula,Electron Kebebew,Karel Pacak,Kong Y. Chen,Francesco S. Celi
标识
DOI:10.1016/j.cmet.2013.12.017
摘要
Rediscovery of cold-activated brown adipose tissue (BAT) in humans has boosted research interest in identifying BAT activators for metabolic benefits. Of particular interest are cytokines capable of fat browning. Irisin, derived from FNDC5, is an exercise-induced myokine that drives brown-fat-like thermogenesis in murine white fat. Here we explored whether cold exposure is an afferent signal for irisin secretion in humans and compared it with FGF21, a brown adipokine in rodents. Cold exposure increased circulating irisin and FGF21. We found an induction of irisin secretion proportional to shivering intensity, in magnitude similar to exercise-stimulated secretion. FNDC5 and/or FGF21 treatment upregulated human adipocyte brown fat gene/protein expression and thermogenesis in a depot-specific manner. These results suggest exercise-induced irisin secretion could have evolved from shivering-related muscle contraction, serving to augment brown fat thermogenesis in concert with FGF21. Irisin-mediated muscle-adipose crosstalk may represent a thermogenic, cold-activated endocrine axis that is exploitable in obesity therapeutics development.
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