Shared dysregulated pathways lead to Parkinson's disease and diabetes

神经退行性变 疾病 糖尿病 胰岛素抵抗 帕金森病 生物信息学 医学 遗传倾向 病因学 生物 内科学 内分泌学
作者
José A. Santiago,Judith A. Potashkin
出处
期刊:Trends in Molecular Medicine [Elsevier]
卷期号:19 (3): 176-186 被引量:179
标识
DOI:10.1016/j.molmed.2013.01.002
摘要

Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic diseases, share remarkably similar dysregulated pathways. Exposure to environmental factors and genetic susceptibility play a role in the etiology and progression of both diseases. In light of recent findings, an intriguing hypothesis has emerged that suggests that mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, and alterations in metabolism may lead to insulin resistance and, ultimately, to diabetes and/or neurodegeneration. In this article, we summarize the studies that have addressed the relationship between Parkinson's disease and diabetes and propose that disruptions in these shared molecular networks lead to both chronic diseases. Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic diseases, share remarkably similar dysregulated pathways. Exposure to environmental factors and genetic susceptibility play a role in the etiology and progression of both diseases. In light of recent findings, an intriguing hypothesis has emerged that suggests that mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, and alterations in metabolism may lead to insulin resistance and, ultimately, to diabetes and/or neurodegeneration. In this article, we summarize the studies that have addressed the relationship between Parkinson's disease and diabetes and propose that disruptions in these shared molecular networks lead to both chronic diseases. is a retrospective epidemiological study that uses registered and self-reported data to compare two or more existing groups. is a clinical study in which one or more groups (called cohorts) are followed prospectively to evaluate a disease or treatment. is a protein hormone that is synthesized in the pancreas from proinsulin and secreted by the pancreatic β cells. is a condition in which the body's cells have a diminished ability to respond to the insulin hormone. is a cluster of conditions including high blood pressure, insulin resistance, and abnormal cholesterol levels that occur together, increasing the risk of heart disease, stroke, and diabetes.
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