脂肪肝
疾病
肥胖
转录组
病理生理学
组学
生物信息学
生理学
肝病
内科学
生物
脂肪组织
医学
基因
基因表达
生物化学
作者
Abraham S. Meijnikman,Dimitra Lappa,Hilde Herrema,Ömrüm Aydin,Kimberly A. Krautkramer,Valentina Tremaroli,Louise E. Olofsson,Annika Lundqvist,Sjoerd C. Bruin,Yair I Z Acherman,Joanne Verheij,Siv A. Hjorth,Victor E. A. Gerdes,Thue W. Schwartz,Albert K. Groen,Fredrik Bäckhed,Jakob Skov Nielsen,Max Nieuwdorp
出处
期刊:iScience
[Elsevier]
日期:2022-08-01
卷期号:25 (8): 104828-104828
被引量:4
标识
DOI:10.1016/j.isci.2022.104828
摘要
Non-alcoholic fatty liver disease (NAFLD) is now the most frequent global chronic liver disease. Individuals with NAFLD exhibited an increased risk of all-cause mortality driven by extrahepatic cancers and liver and cardiovascular disease. Once the disease is established, women have a higher risk of disease progression and worse outcome. It is therefore critical to deepen the current knowledge on the pathophysiology of NAFLD in women. Here, we used a systems biology approach to investigate the contribution of different organs to this disease. We analyzed transcriptomics profiles of liver and adipose tissues, fecal metagenomes, and plasma metabolomes of 55 women with and without NAFLD. We observed differences in metabolites, expression of human genes, and gut microbial features between the groups and revealed that there is substantial crosstalk between these different omics sets. Multi-omics analysis of individuals with NAFLD may provide novel strategies to study the pathophysiology of NAFLD in humans.
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