PLGA公司
生物相容性
生物医学工程
脚手架
骨膜
材料科学
松质骨
乙醇酸
骨愈合
髂嵴
3d打印
解剖
乳酸
医学
纳米技术
细菌
冶金
纳米颗粒
生物
遗传学
作者
Ge Zhang,Xianfeng Tian,Boon Chin Heng,Victor Fan,Jin-Fei Yeo,Tong Cao
标识
DOI:10.1088/1748-6041/4/2/021001
摘要
Utilizing a suitable combination of lactide and glycolide in a copolymer would optimize the degradation rate of a scaffold upon implantation in situ. Moreover, 3D printing technology enables customizing the shape of the scaffold to biometric data from CT and MRI scans. A previous in vitro study has shown that novel 3D-printed poly-lactic-co-glycolic acid (PLGA) scaffolds had good biocompatibility and mechanical properties comparable with human cancellous bone, while they could support proliferation and osteogenic differentiation of osteoblasts. Based on the previous study, this study evaluated PLGA scaffolds for bone regeneration within a rabbit model. The scaffolds were implanted at two sites on the same animal, within the periosteum and within bi-cortical bone defects on the iliac crest. Subsequently, the efficacy of bone regeneration within the implanted scaffolds was evaluated at 4, 12 and 24 weeks post-surgery through histological analysis. In both the intra-periosteum and iliac bone defect models, the implanted scaffolds facilitated new bone tissue formation and maturation over the time course of 24 weeks, even though there was initially observed to be little tissue ingrowth within the scaffolds at 4 weeks post-surgery. Hence, the 3D-printed porous PLGA scaffolds investigated in this study displayed good biocompatibility and are osteoconductive in both the intra-periosteum and iliac bone defect models.
科研通智能强力驱动
Strongly Powered by AbleSci AI