药物发现
化学
纳米技术
透视图(图形)
例证
蛋白质降解
数据科学
化学生物学
计算生物学
计算机科学
人工智能
生物化学
认识论
哲学
材料科学
标识
DOI:10.1021/acs.jmedchem.7b01272
摘要
Targeted protein degradation, using bifunctional small molecules (Protacs) to remove specific proteins from within cells, has emerged as a novel drug discovery strategy with the potential to offer therapeutic interventions not achievable with existing approaches. In this Perspective, the brief history of the field is surveyed from a drug discovery perspective with a focus on the key advances in knowledge which have led to the definition and exemplification of protein degradation concepts and their resulting applications to medicine discovery. The approach has the potential to bring disruptive change to drug discovery; the many potential advantages and outstanding challenges which lie ahead of this technology are discussed.
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