已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Prevalence of a decreased FEV3/FEV6 ratio in symptomatic smokers with preserved lung function

医学 四分位间距 内科学 慢性阻塞性肺病 DLCO公司 慢性支气管炎 肺功能测试 心脏病学 肺活量 支气管炎 肺功能 扩散能力
作者
T. Kanouté,A. Simon,D. Muti,D. Caillaud,Frédéric Costes
出处
期刊:Respiratory medicine and research [Elsevier]
卷期号:81: 100891-100891 被引量:3
标识
DOI:10.1016/j.resmer.2022.100891
摘要

The ratio of forced expiratory volume in 3 seconds to forced expiratory volume in 6 seconds (FEV3/FEV6) has been proposed as an index of peripheral airway disease, and could be decreased in patients at risk for COPD. However, the prevalence of FEV3/FEV6 decrease has never been assessed in patients attending a pneumology clinic. Here we set out to assess the prevalence of a decreased FEV3/FEV6 in smokers with symptoms of chronic bronchitis, and to test its predictive value for COPD diagnosis.We performed a retrospective analysis of databased pulmonary function tests (PFTs) for smokers and ex-smokers aged >40 years old, with symptoms of chronic bronchitis and a normal FEV1/FVC ratio. Clinical data were retrieved from the hospital records. Patients presenting with clinical conditions liable to interfere with PFT results were excluded. For those included, we controlled for onset of an obstructive ventilatory defect 1 year later.The dataset included 67 patients (median age: 64 years [interquartile range: 53-72], 61% current smokers). FEV1/FVC was above lower limit of normal but lower than 0.7 in 18 patients (27%). FEV3/FEV6 was decreased below the lower limit of normal in 45 patients (67%). The latter did not differ from others patients in clinical data and PFTs except for a lower lung diffusion capacity (DLCO). We found a weak correlation between FEV3/FEV6 and DLCO (r=0.33, p=0.004). PFTs were repeated in 35 patients at 11 [7-12] months, and 20 (54%) presented with obstructive ventilatory defect defined by FEV1/FVC ratio <0.7. A reduction of FEV3/FEV6 was predictive of COPD onset one year later (p=0.04). These results may be biased by a discrepancy between the normality cut-offs used at inclusion and during follow-up (i.e. lower limit of normal and 0.7).Decreased FEV3/FEV6 suggestive of peripheral airway disease is highly prevalent in smokers with symptoms of chronic bronchitis and preserved pulmonary function. Altered FEV3/FEV6 is predictive of reduced FEV1/FVC ratio in the mid-term. A larger prospective study is needed to determine whether decreased FEV3/FEV6 could be used to detect patients at risk for COPD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
追寻的问安完成签到 ,获得积分10
2秒前
Owen应助CLQ采纳,获得10
2秒前
4秒前
6秒前
9秒前
11秒前
gjww应助ccc采纳,获得10
11秒前
含含含发布了新的文献求助10
11秒前
CLQ发布了新的文献求助10
14秒前
研友_Lk9Y9Z发布了新的文献求助10
18秒前
VanMo完成签到 ,获得积分10
19秒前
20秒前
wyy关闭了wyy文献求助
22秒前
23秒前
易知发布了新的文献求助30
23秒前
gjww应助含含含采纳,获得10
24秒前
星辰完成签到 ,获得积分10
32秒前
33秒前
sswbzh应助易知采纳,获得30
33秒前
heheda发布了新的文献求助10
36秒前
36秒前
斯文败类应助胡二皮采纳,获得10
36秒前
37秒前
秋雪瑶应助医学僧采纳,获得30
37秒前
gyl完成签到 ,获得积分10
37秒前
王博士发布了新的文献求助10
40秒前
41秒前
谦让的静柏完成签到 ,获得积分10
42秒前
43秒前
46秒前
47秒前
研人员完成签到,获得积分10
48秒前
0℃发布了新的文献求助10
50秒前
研人员发布了新的文献求助10
50秒前
科研通AI2S应助ziwi采纳,获得10
53秒前
丘比特应助二行采纳,获得10
54秒前
Cara发布了新的文献求助10
54秒前
zxt完成签到 ,获得积分10
56秒前
0℃完成签到,获得积分10
56秒前
wyy发布了新的文献求助20
57秒前
高分求助中
Sraffa and applied economics: are there classical supply curves? 1000
Heun’s Differential Equations 600
《Fundamentals of Power Supply Design》Robert A. Mammano 510
谁能看见前面有梦可想 500
Wind Effects on Structures: An Introduction to Wind Engineering and Wind Forces in Engineering (2nd Edition) 300
Against the Grain: The Vayda Tradition in Human Ecology and Ecological Anthropology 300
High Wire: How China Regulates Big Tech and Governs Its Economy 260
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2248916
求助须知:如何正确求助?哪些是违规求助? 1898217
关于积分的说明 4733297
捐赠科研通 1687364
什么是DOI,文献DOI怎么找? 856232
版权声明 545097
科研通“疑难数据库(出版商)”最低求助积分说明 453077