ISG15
干扰素
生物
结核分枝杆菌
免疫
Ⅰ型干扰素
细胞内寄生虫
基因
肺结核
病毒学
免疫系统
免疫学
遗传学
泛素
医学
病理
作者
Zilu Wang,Tongxin Li,Zhizhong Gong,Jingwei Xie
标识
DOI:10.1016/j.cellsig.2022.110329
摘要
ISG15 encoded by a type I interferon (IFN) inducible gene mediates an important cellular process called ISGylation. ISGylation emerges as a powerful host tactic against intracellular pathogens like Mycobacterium tuberculosis (Mtb). However, the exact role of ISGylation in immunity remains elusive. To shed light on how ISGylation, which is both interesting and complex, participates in immunity against Mtb, this manuscript summarized the current knowledge about the structural characteristics and targets of ISG15 and how ISGylation cross-talks with other host post-translational modifications to exert its effect.
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