微生态学
球体
癌症研究
细胞生物学
细胞
肿瘤微环境
癌症
生物
肿瘤细胞
化学
细胞培养
生物化学
生态学
遗传学
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1988-04-08
卷期号:240 (4849): 177-184
被引量:1657
标识
DOI:10.1126/science.2451290
摘要
Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.
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