核糖核酸
转录组
计算生物学
生物
核酸结构
RNA序列
功能(生物学)
核糖开关
基因
非编码RNA
遗传学
基因表达
作者
Yao Wan,Michael A. Kertesz,Robert C. Spitale,Eran Segal,Howard Y. Chang
摘要
The ways in which an RNA molecule folds to form structures can be crucial to its function, and so methods for studying RNA structures make an important contribution to understanding transcriptomes. Experimental approaches in this field are being advanced by coupling them to high-throughput sequencing. RNA structure is crucial for gene regulation and function. In the past, transcriptomes have largely been parsed by primary sequences and expression levels, but it is now becoming feasible to annotate and compare transcriptomes based on RNA structure. In addition to computational prediction methods, the recent advent of experimental techniques to probe RNA structure by high-throughput sequencing has enabled genome-wide measurements of RNA structure and has provided the first picture of the structural organization of a eukaryotic transcriptome — the 'RNA structurome'. With additional advances in method refinement and interpretation, structural views of the transcriptome should help to identify and validate regulatory RNA motifs that are involved in diverse cellular processes and thereby increase understanding of RNA function.
科研通智能强力驱动
Strongly Powered by AbleSci AI