癌症研究
肿瘤微环境
肿瘤相关巨噬细胞
巨噬细胞极化
癌症免疫疗法
免疫疗法
巨噬细胞
吞噬作用
医学
肿瘤进展
表型
癌症
免疫学
免疫系统
生物
体外
肿瘤细胞
内科学
基因
生物化学
作者
Chunxiao Li,Xiaofei Xu,Shuhua Wei,Ping Jiang,Lixiang Xue,Junjie Wang
标识
DOI:10.1136/jitc-2020-001341
摘要
Macrophages are the most important phagocytes in vivo. However, the tumor microenvironment can affect the function and polarization of macrophages and form tumor-associated macrophages (TAMs). Usually, the abundance of TAMs in tumors is closely associated with poor prognosis. Preclinical studies have identified important pathways regulating the infiltration and polarization of TAMs during tumor progression. Furthermore, potential therapeutic strategies targeting TAMs in tumors have been studied, including inhibition of macrophage recruitment to tumors, functional repolarization of TAMs toward an antitumor phenotype, and other therapeutic strategies that elicit macrophage-mediated extracellular phagocytosis and intracellular destruction of cancer cells. Therefore, with the increasing impact of tumor immunotherapy, new antitumor strategies to target TAMs are now being discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI