祖细胞
间充质
生物
人口
细胞生物学
间质细胞
间充质干细胞
细胞分化
输尿管芽
干细胞
肾单位
再生(生物学)
祖细胞
细胞命运测定
胚胎干细胞
免疫学
肾
电池类型
细胞
肾脏发育
内分泌学
遗传学
癌症研究
医学
基因
环境卫生
作者
Raphael Kopan,Shuang Chen,Melissa H. Little
出处
期刊:Current Topics in Developmental Biology
日期:2014-01-01
卷期号:: 293-331
被引量:73
标识
DOI:10.1016/b978-0-12-416022-4.00011-1
摘要
Within the developing mammalian kidney, several populations of progenitors form the discrete cellular components of the final organ. Fate mapping experiments revealed the cap mesenchyme (CM) to be the progenitor population for all nephron epithelial cells, whereas the neighboring stromal mesenchyme gives rise to mesangial, pericytic, renin-producing and interstitial cells. The collecting ducts are derived from a population of progenitors at the ureteric bud (UB) tip and a proportion of the endothelium is also derived from a dedicated mesenchymal progenitor. The stroma, CM, and UB interact to create spatially defined niches at the periphery of the developing organ. While the UB tip population persist, the CM represents a transient progenitor population that is exhausted to set the final organ size. The timing of CM exhaustion, and hence the final organ structure, is sensitive to disruptions such as premature birth. Here we will discuss our current understanding of the molecular processes allowing these populations to balance cell survival, self-renewal, support of branching, and maintain capacity to commit to differentiation.
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