内科学
内分泌学
胰岛素抵抗
多囊卵巢
高同型半胱氨酸血症
雌激素
脂肪组织
巨噬细胞极化
糖耐量受损
炎症
胰岛素
同型半胱氨酸
生物
医学
巨噬细胞
生物化学
体外
作者
Xinyu Qi,Bochun Zhang,Yue Zhao,Rong Li,Hsun‐Ming Chang,Yanli Pang,Jie Qiao
出处
期刊:Endocrinology
[The Endocrine Society]
日期:2017-03-15
卷期号:158 (5): 1181-1193
被引量:26
标识
DOI:10.1210/en.2017-00039
摘要
It has been shown that serum homocysteine (Hcy) levels are higher in women with polycystic ovary syndrome (PCOS). However, the specific role of hyperhomocysteinemia (HHcy) in the development of PCOS has never been reported. Adipose tissue inflammation is featured by the infiltration of macrophages, which plays a critical role in the pathogenesis of glucose and insulin intolerance. In this study, C57BL/6 mice were treated with dehydroepiandrosterone (DHEA) and/or a high methionine diet to induce PCOS and HHcy mice models. We showed that DHEA induced a PCOS-like phenotypes, irregular estrous cycles, weight gain, abnormal sex hormone production, glucose and insulin resistance, and polycystic ovaries. HHcy further intensified the effects DHEA on the metabolic, endocrinal, hormonal, and morphological changes in PCOS-like mice. In addition, HHcy attenuated the DHEA-induced increase in serum estrogen levels in mice. Furthermore, HHcy may exacerbate the insulin resistance in PCOS-like mice, most likely through modulating the macrophage M1/M2 polarization pathways via the suppression of estrogen. Most important, our clinical data showed that there were increases in serum Hcy levels in patients with PCOS. These findings deepen our understanding of the pathological roles of HHcy in the development of PCOS and provide a promising target for PCOS therapy in clinical application.
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