猴痘
牛痘
病毒学
爆发
正痘病毒
病毒
天花疫苗
接种疫苗
大流行
痘病毒科
2019年冠状病毒病（COVID-19）
生物
医学
疾病
基因
传染病（医学专业）
重组DNA
遗传学
病理
作者
Entao Li,Qizan Gong,Jiachen Zhang,Xiaoping Guo,Wenyu Xie,Da Chen,Yanqiong Shen,Dongxiang Hong,Zhihao Li,Qianqian Wang,Chao Wang,Yucai Wang,Sandra Chiu
标识
DOI：10.1016/j.antiviral.2024.105974
摘要
The outbreak of 2022 monkeypox virus (MPXV) infection in nonendemic regions is a global public health concern. A highly effective and safe MPXV vaccine that is available to the general public is urgently needed to control the mpox pandemic. Here, we developed a multivalent mRNA vaccine candidate, MPXV-1103, which expresses the full-length B6, A35, A29 and M1 proteins with three flexible linkers (G
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