[Study on feasibility of HaCaT epidermal model as an alternative to skin irritation in vitro].

The epidermal model of HaCaT cells does not possess the complete epidermal physiological structure, the barrier function as ET ₅₀ of the HaCaT model is lower than EpiKutis ^® model, the chemicals in vitro skin irritation test results do not meet the OECD criteria for the determination of stimulants, so the HaCaT model is not suitable as a replacement tool in vitro to determine the chemicals skin irritation.