生物
祖细胞
IRF8
浆细胞样树突状细胞
祖细胞
髓样
树突状细胞
细胞生物学
转录因子
免疫学
淋巴细胞生成
滤泡树突状细胞
免疫系统
干细胞
T细胞
基因
抗原提呈细胞
遗传学
作者
Patrick Fernandes Rodrigues,Llucia Albertí-Servera,А. В. Еремин,Gary E. Grajales‐Reyes,Robert Ivánek,Roxane Tussiwand
标识
DOI:10.1038/s41590-018-0136-9
摘要
Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts of type 1 interferons in response to viral infections. Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. Here, we found that pDCs developed predominantly from IL-7R+ lymphoid progenitor cells. Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch. Transcriptional characterization of SiglecH+Ly6D+ precursors indicated that pDC development requires high expression of the transcription factor IRF8, whereas pDC identity relies on TCF4. RNA sequencing of IL-7R+ lymphoid and CDP-derived pDCs mirrored the heterogeneity of mature pDCs observed in single-cell analysis. Both mature pDC subsets are able to secrete type 1 interferons, but only myeloid-derived pDCs share with cDCs their ability to process and present antigen.
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