药代动力学
医学
恩曲他滨
药理学
最大值
置信区间
曲线下面积
尿
作者
Wen-Li Han,Jing-Chuan Shang,Bo Yan,Rui Tan,Wen-xiang Huang,Xiao-Ni Zhong,Jun-Qing Yang,Ai-Long Huang
出处
期刊:Pharmacology
[S. Karger AG]
日期:2014-01-01
卷期号:93: 166-171
摘要
Emtricitabine (FTC) is used for the treatment of HIV infection and pre-exposure chemoprophylaxis. It is often used in combination with tenofovir disoproxil fumarate (TDF). This study was designed to evaluate FTC pharmacokinetics in healthy male Chinese volunteers. Sixty subjects were recruited into this single-centre, randomised, open-label study and randomly received single (groups A, B and C) or multiple oral doses (once daily for 6 days; groups D, E and F) of 200-mg FTC capsules alone (A and D), or combined with 300-mg TDF tablets (B and E), or 200 mg of FTC plus 300 mg of TDF with a high-fat diet (C and F), respectively. FTC was well-tolerated in all groups. After a single dose, there were no differences in the mean AUC0-∞ values; however, there were significant differences in the mean Tmax values (1.05, 1.40 and 2.10 h for groups A, B and C, respectively; p 1/2 values following single-dose FTC.
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