地穴
化学
冠醚
分子
组合化学
配体(生物化学)
乙醚
药物输送
立体化学
受体
离子
有机化学
生物化学
作者
Shanshan Wang,Zhe Huang,Anyang Li,Yanxia Zhao,Wei Zuo,Yawen Li,Haohao Miao,Jiacheng Ma,Wei Sun,Xiaoqing Wang,Liping Cao,Biao Wu,Chuandong Jia
标识
DOI:10.1002/anie.202100441
摘要
In many critical biological processes, host-guest chemistry of protein receptors is regulated by effector molecules to realize cascaded delivery of messenger molecules between different targets. Mimicking these natural processes with artificial receptors remains a challenge. Herein, we report a cascaded guest delivery between two anionocages (anion-coordination-driven cages), in a reversible manner, wherein binding of K+ ions by a crown ether functionalized, heteroleptic A2 L3 (A=anion, L=ligand) anionocage triggers the release and delivery of a TEA+ (tetraethylammonium) guest to another A2 L3 anionocage that is a weaker and less K+ -sensitive receptor. Elimination of the K+ with [2,2,2]-cryptand enables recapture of the TEA+ by the crown ether functionalized anionocage and thus realizes a reversed guest delivery. Moreover, integrative self-sorting of anionocages is firstly reported, leading to heteroleptic cages with enhanced guest binding affinities.
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