High-entropy ceramics can be transformative for several applications, but the development of this class of materials is limited by costly and time-consuming experimental processes. The disordered enthalpy–entropy descriptor is a mathematical formula that accelerates the computational discovery of synthesizable high-entropy ceramics, and has already guided the synthesis of nine new high-entropy carbonitrides and borides. A mathematical equation that considers the balance between enthalpy and entropy can be used to help synthesize disordered ceramics.