Ten millennia of hepatitis B virus evolution

病毒学史前史大流行病毒地理谱系（遗传）祖先生物扩散乙型肝炎病毒生物遗传多样性人类迁徙民族学考古人口学 2019年冠状病毒病（COVID-19）历史遗传学医学基因人口传染病（医学专业）疾病社会学病理

作者

Arthur Kocher,Luka Papac,Rodrigo Barquera,Felix M. Key,Maria A. Spyrou,Ron Hübler,Adam B. Rohrlach,Franziska Aron,Raphaela Stahl,Antje Wissgott,Florian van Bömmel,Maria Pfefferkorn,Alissa Mittnik,Vanessa Villalba‐Mouco,Gunnar U. Neumann,Maïté Rivollat,Marieke S. van de Loosdrecht,Kerttu Majander,Rezeda I. Tukhbatova,Lyazzat Musralina,Ayshin Ghalichi,Sandra Penske,Susanna Sabin,Megan Michel,Joscha Gretzinger,Elizabeth A. Nelson,Tiago Ferraz,Kathrin Nägele,Cody Parker,Marcel Keller,Evelyn K. Guevara,Michal Feldman,Stefanie Eisenmann,Eirini Skourtanioti,Karen Giffin,Guido Alberto Gnecchi‐Ruscone,Susanne Friederich,Vittoria Schimmenti,Valery Khartanovich,Marina K. Karapetian,Mikhail S. Chaplygin,Vladimir V. Kufterin,Aleksandr Khokhlov,Andrey A. Chizhevsky,Dmitry A. Stashenkov,Anna F. Kochkina,Cristina Tejedor Rodríguez,Íñigo García-Martínez de Lagrán,Héctor Arcusa-Magallón,Rafael Garrido Peña,José I. Royo-Guillén,Jan Nováček,Stéphane Rottier,Sacha Kacki,Sylvie Saintot,Elena Kaverzneva,Andrej B. Belinskiy,Petr Velemínský,Petr Limburský,Michal Kostka,Louise Loe,Elizabeth Popescu,Rachel Clarke,Alice Lyons,Richard Mortimer,Antti Sajantila,Yadira Chinique de Armas,Silvia Teresita Hernández Godoy,Diana Iraíz Hernández-Zaragoza,Jessica Pearson,Didier Binder,Philippe Lefranc,А. Р. Канторович,Vladimir Е. Maslov,Luca Lai,Magdalena Żołędziewska,Jessica F. Beckett,Michaela Langová,Alžběta Danielisová,Tara Ingman,Gabriel García Atiénzar,María Paz de Miguel Ibáñez,Alejandro Romero,Alessandra Sperduti,Sophie Beckett,Susannah J. Salter,Emma D. Zilivinskaya,Dmitry V. Vasil’ev,Kristin von Heyking,Richard L. Burger,Lucy C. Salazar,Luc Amkreutz,Masnav Navruzbekov,Eva Rosenstock,Carmen Alonso Fernández,Vladimir Slavchev,Alexey Kalmykov,Biaslan Ch. Atabiev,Elena Batieva,Micaela Álvarez Calmet,Bastien Llamas,Michael Schultz,Raiko Krauß,Javier Jiménez Echevarría,Michael Francken,Светлана Шнайдер,Peter de Knijff,Eveline Altena,Katrien Van de Vijver,Lars Fehren‐Schmitz,Tiffiny A. Tung,Sandra Lösch,Maria V. Dobrovolskaya,Nikolaj Makarov,Chris Read,Melanie Van Twest,Claudia Sagona,Peter C. Ramsl,Murat Akar,K. Aslıhan Yener,Eduardo Carmona Ballestero,Francesco Cucca,Vittorio Mazzarello,Pilar Utrilla,Kurt Rademaker,Eva Fernández‐Domínguez,Douglas Baird,Patrick Semal,Lourdes Márquez Morfín,Mirjana Roksandić,Hubert Steiner,Domingo C. Salazar‐García,Natalia Shishlina,Yılmaz Selim Erdal,Fredrik Hallgren,Yavor Boyadzhiev,Kamen Boyadzhiev,Mario Küßner,Duncan Sayer,Päivi Onkamo,Robin Skeates,Manuel Ángel Rojo Guerra,Alexandra P. Buzhilova,Elmira Khussainova,Leyla Djansugurova,A. Beisenov,З. Самашев,Ken Massy,Marcello A. Mannino,Vyacheslav Moiseyev,Kristiina Mannermaa,Oleg Balanovsky,Marie‐France Deguilloux,Sabine Reinhold,Svend Hansen,Еgor Kitov,Miroslav Dobeš,Michal Ernée,Harald Meller,Kurt W. Alt,Kay Prüfer,Christina Warinner,Stephan Schiffels,Philipp W. Stockhammer,Kirsten I. Bos,Cosimo Posth,Alexander Herbig,Wolfgang Haak,Johannes Krause,Denise Kühnert

出处

期刊：Science [American Association for the Advancement of Science]
日期：2021-10-08 卷期号：374 (6564): 182-188 被引量：85

链接

hal.science au.dk au.dk au.dk ac.uk ac.uk handle.net csic.es ac.uk ac.uk oclc.org oclc.org handle.net universiteitleiden.nl nih.govdoi.org

标识

DOI：10.1126/science.abi5658

摘要

Ancient DNA traces the history of hepatitis B Hepatitis B virus (HBV) infections represent a worldwide human health concern. To study the history of this pathogen, Kocher et al . identified 137 human remains with detectable levels of virus dating between 400 and 10,000 years ago. Sequencing and analyses of these ancient viruses suggested a common ancestor between 12,000 and 20,000 years ago. There is no evidence indicating that HBV was present in the earliest humans as they spread out of Africa; however, HBV was likely present in human populations before farming. Furthermore, the virus was present in the Americas by about 9000 years ago, representing a lineage sister to the viral strains found in Eurasia that diverged about 20,000 years ago. —LMZ

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Ten millennia of hepatitis B virus evolution

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