Exploring the Multifaceted Potential of Natural Flavonoid Diosmetin in Human Diseases

Abstract: Flavonoids are secondary metabolites that are closely related to polyphenols and have a diverse structure. These are present in the form of aglycones or glycosides in many fruits and vegetables. Diosmetin (DIO) is a bioactive flavonoid primarily found in the olive tree (Olea europaea L) and has been recognised for its diverse therapeutic potential in the management of many illnesses. In recent years, multiple pharmacological properties of DIO have been shown, including anti-inflammatory, antioxidant, antimicrobial, cardioprotective, hepatoprotective, renal protective, lung protective, retinal protective, neuroprotective and anticancer activity. Therefore, considering the pharmacological potential of DIO, the present work was designed to further explore its pharmacological actions in the treatment of various diseases.