Bacillisporins D and E, New Oxyphenalenone Dimers from Talaromyces bacillisporus

The oligophenalenone dimer duclauxin and two new analogues, bacillisporins D and E, were isolated from the fungus Talaromyces bacillisporus in addition to the previously reported bacillisporins A, B and C. Structures were established by spectroscopic studies. Duclauxin and bacillisporins A, B, C and E were evaluated for cytotoxicity against three human cancer cell lines. Bacillisporin A was strongly active against MCF-7 and NCI-H460 and moderately active against SF-268 while bacillisporins B, C and duclauxin were moderately active against all three cell lines.