Efficacy and safety of bacterial immunostimulants in immunodeficient individuals: A systematic review and meta‐analysis

Bacterial immunostimulants, particularly OM-85, show promise as adjuncts in the management of immunodeficiencies by reducing ARTIs and antibiotic use, and enhancing immune responses. They are well-tolerated, with no evidence of pathological immune activation. However, study heterogeneity and methodological differences limit comparability.