Hyperoxaluria in Kidney Stone Formers Treated With Modern Bariatric Surgery

No AccessJournal of UrologyAdult urology1 Feb 2007Hyperoxaluria in Kidney Stone Formers Treated With Modern Bariatric Surgery John R. Asplin and Fredric L. Coe John R. AsplinJohn R. Asplin and Fredric L. CoeFredric L. Coe View All Author Informationhttps://doi.org/10.1016/j.juro.2006.09.033AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Nephrolithiasis and renal failure secondary to severe hyperoxaluria were complications of jejunoileal bypass for obesity, leading to the discontinuation of this procedure in the United States in 1980. Bariatric procedures currently in use have not been adequately evaluated for this complication. Materials and Methods: We compared 24-hour urine chemistry studies of 132 patients with nephrolithiasis who had undergone bariatric surgery with the urine chemistry studies of patients who had undergone jejunoileal bypass, those with routine kidney stones and normal subjects. The primary aim was to determine if hyperoxaluria developed in patients who underwent bariatric surgery and had kidney stones as had been seen with jejunoileal bypass. Results: Patients who have undergone modern bariatric surgery had an adjusted mean urine oxalate excretion of 83 mg per day compared to 39 mg per day for routine kidney stone formers and 34 mg per day for normal subjects (p <0.001 for both comparisons), but not quite as high as that found in patients treated with jejunoileal bypass (102 mg per day, p <0.001). Urine supersaturation of calcium oxalate, the main driving force for calcium oxalate stone formation, was higher in patients treated with bariatric surgery compared to routine kidney stone formers and normal subjects (p <0.001 for both comparisons). Conclusions: Hyperoxaluria is the most significant abnormality of urine chemistry studies in patients with kidney stones who have undergone bariatric surgery. Many of these patients have a degree of hyperoxaluria that could lead to kidney failure. Further studies are required to determine the prevalence of this problem in patients who have undergone bariatric surgery. References 1 : Prevalence and trends in obesity among US adults, 1999–2000. JAMA2002; 288: 1723. Google Scholar 2 : The obesity pandemic: where have we been and where are we going?. Obes Res2004; 12: 88. Google Scholar 3 : Excessive mortality and causes of death in morbidly obese men. JAMA1980; 243: 443. 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Volume 177Issue 2February 2007Page: 565-569 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsgastric bypassjejunoileal bypassurinary calculiobesityoxalatesAcknowledgmentsJoan Parks and Susan Donahue provided assistance.MetricsAuthor Information John R. Asplin Financial interest and/or other relationship with Litholink Corp. More articles by this author Fredric L. Coe Financial interest and/or other relationship with Litholink Corp. More articles by this author Expand All Advertisement PDF downloadLoading ...