42910 Validation of the Sleep Numeric Rating Scale (Sleep-NRS) for measuring sleep quality in adults with Prurigo Nodularis (PN): Results from dupilumab clinical studies

Background: Introduction Patients with prurigo nodularis (PN) often experience poor sleep quality due to night-time awakenings resulting from pruritus. The Sleep-Numeric Rating Scale (Sleep-NRS; scale of 0 [worst possible sleep] to 10 [best possible sleep] that describes sleep quality last night) has been used as a measure of patients' sleep quality in clinical trials in atopic dermatitis. There is no published evidence on validation of its psychometric properties in PN. We evaluated the psychometric properties of Sleep- NRS in adult patients with PN, to support its use as an endpoint in dupilumab trials.