ATROPINE ROLE IN THE PHARMACOLOGICAL ERECTION TEST: STUDY OF 228 PATIENTS

No AccessJournal of UrologyClinical Urology: Original Articles1 Nov 1997ATROPINE ROLE IN THE PHARMACOLOGICAL ERECTION TEST: STUDY OF 228 PATIENTS Paulo Roberto Sogari, Claudio Teloken, and Carlos Ary Vargas Souto Paulo Roberto SogariPaulo Roberto Sogari , Claudio TelokenClaudio Teloken , and Carlos Ary Vargas SoutoCarlos Ary Vargas Souto View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64122-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined the efficacy of atropine sulfate combined with papaverine hydrochloride, prostaglandin E1 and phentolamine mesylate in the pharmacological erection test. Materials and Methods: A total of 230 consecutive patients with erectile dysfunction was randomized for pharmacological erection test and received an intracorporeal combination of 50 mg. papaverine hydrochloride, 10 micro g. prostaglandin E1, 0.2 mg. phentolamine mesylate and 0.075 mg. of atropine sulfate (group 1), or the same combination without atropine sulfate (group 2). Erectile response was evaluated subjectively and by intracorporeal pressure measurement. Results: In group 1, 40 patients (35.1%) showed only tumescence, and 22 (19.3%) had poor erection. In group 2, 45 patients (39.5%) had tumescence and 17 (14.9%) poor erection. In both groups 52 patients (45.6%) had rigid erection. There was no statistically significant difference regarding erectile response and intracorporeal pressure. Conclusions: The addition of atropine sulfate did not improve results of the pharmacological erection test when combined with 50 mg. papverine hydrochloride, 10 micro g., prostaglandin E1, and 0.2 mg. phentolamine mesylate. References 1 : Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J. Urol.1994; 151: 54. Link, Google Scholar 2 : Pathophysiology of erectile dysfunction. Urology1993; 42: 468. Google Scholar 3 : A prospective double-blind trail of intracorporeal papaverine versus prostaglandin E1 in the treatment of impotence. J. Urol.1989; 141: 551. Abstract, Google Scholar 4 : Prostaglandin E1 therapy for impotence, comparison with papaverine. J. Urol.1990; 143: 57. Link, Google Scholar 5 : Prostaglandin E1 versus papaverine for diagnosis of erectile dysfunction. Int. J. Impotence Res., suppl.1990; 23: 127. Google Scholar 6 : Comparison of effects following the intracorporeal injection of papaverine and prostaglandin E1. Brit. J. Urol.1992; 69: 404. Google Scholar 7 : Use of atropine sulfate in pharmacologic erections: initial experience with one year follow-up in the United States. J. Urol.1992; 147: 265A. part 2, abstract, 206. Google Scholar 8 : Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-year experience with 615 cases. J. Urol.1991; 145: 287. Link, Google Scholar 9 : Effectiveness and safety of multidrug intracavernous therapy for vasculogenic impotence. Urology1993; 42: 554. Google Scholar 10 : Four-drug intracavernous therapy for impotence due to corporeal veno-occlusive dysfunction. J. Urol.1993; 149: 1291. Link, Google Scholar 11 : Five and six vasoactive drugs combination for diagnosis and treatment of impotence. Int. J. Impotence Res.1994; 6: D1544. Google Scholar 12 : Estatistica. Sao Paulo: Makron Books do Brasil Editora Ltda1993. Google Scholar 13 : Intracavernous drug-induced erections in the management of male erectile dysfunction: experience with 100 patients. J. Urol.1986; 135: 704. Link, Google Scholar 14 : Intracavernous pharmacotherapy for impotence: selection of appropriate agent and dose. J. Urol.1993; 149: 1288. Link, Google Scholar 15 : Intracavernous self-injection for impotence: a long-term therapeutic option? Experience in 78 patients. J. Urol.1988; 140: 972. Link, Google Scholar 16 : Psychologic factors affect erectile response to papaverine. Urology1991; 38: 294. Google Scholar 17 : Impotence. New Engl. J. Med.1989; 321: 1648. Google Scholar 18 : The combined intracavernous injection and stimulation test: diagnostic accuracy. J. Urol.1992; 148: 61. Link, Google Scholar 19 : Intracavernous injection of prostaglandin E1 in combination with papaverine: enhanced effectiveness in comparison with papaverine plus phentolamine and prostaglandin E1 alone. J. Urol.1991; 145: 56. Link, Google Scholar 20 : An improved vasoactive drug combination for a pharmacological erection program. J. Urol.1991; 146: 1564. Google Scholar 21 : Experience with triple-drug therapy in a pharmacological erection program. J. Urol.1993; 150: 1822. Abstract, Google Scholar 22 : Clinical reliability of multi-drug intracavernous vasoactive pharmacotherapy for diabetic impotence. Acta Diabetol.1994; 31: 1. Google Scholar 23 : Is intracavernous injection of papaverine a reliable screening test for vascular impotence?. J. Urol.1986; 135: 476. Link, Google Scholar 24 : Pharmacotherapy for impotence. Curr. Opin. Urol.1994; 4: 336. Google Scholar 25 : Diagnostic intracorporeal papaverine and erectile dysfunction, Brit. J. Urol.1987; 59: 264. Google Scholar 26 : The reability of the papaverine test as a screening test for vascular disease in impotence. Int. J. Impotence Res.1990; 2: 133. Google Scholar 27 : Hemodynamics of erection. In: Contemporary management of impotence and infertility. Edited by . Baltimore: Williams & Wilkins1988: 28. chapt. 2. Google Scholar 28 : Pharmacological erection: diagnosis and treatment applications in 69 patients. J. Urol.1987; 138: 52. Link, Google Scholar 29 : Intracavernous injection of prostaglandin E1 in impotent men. J. Urol.1988; 140: 66. Link, Google Scholar 30 : Impotence evaluated by the use of prostaglandin E1. J. Urol.1989; 141: 1357. Link, Google Scholar From the Department of Urology, Santa Casa de Porto Alegre, Brazil.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 158Issue 5November 1997Page: 1760-1763 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Paulo Roberto Sogari More articles by this author Claudio Teloken More articles by this author Carlos Ary Vargas Souto More articles by this author Expand All Advertisement PDF downloadLoading ...