Lv71
3910 积分 2021-03-03 加入
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor
1个月前
已完结
Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760
2个月前
已完结
Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors
3个月前
已完结
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
3个月前
已完结
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets
3个月前
已完结
Development of potent and selective CK1α Molecular Glue Degraders
4个月前
已完结
Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library
4个月前
已完结
On the relationship between hERG inhibition and the magnitude of QTc prolongation: An in vitro to clinical translational analysis
4个月前
已完结
FFLOM: A Flow-Based Autoregressive Model for Fragment-to-Lead Optimization
4个月前
已完结
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
4个月前
已完结
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