Lv71
3240 积分 2021-03-03 加入
Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen
1天前
已完结
Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers
4天前
已完结
Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9
23天前
已完结
Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo
1个月前
已完结
Discovery of Naphthyridinone Derivatives as Selective and Potent PKMYT1 Inhibitors with Antitumor Efficacy
2个月前
已完结
A structural basis for amylin receptor phenotype
2个月前
已完结
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
2个月前
已完结
Covalent-Allosteric Inhibitors: Do We Get the Best of Both Worlds?
3个月前
已完结
Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers
3个月前
已完结
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor
4个月前
已完结
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