Lv5130
802 积分 2023-07-05 加入
Derisking Affinity Optimization for Macrocycles and Cyclic Peptides: High-Precision Free Energy Simulations across Five Diverse Targets
4天前
已完结
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
5天前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
7天前
已完结
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
7天前
已完结
In silico prediction of chemical genotoxicity using machine learning methods and structural alerts
25天前
已完结
Reliability-Aware Deep Learning Framework for Chemical Genotoxicity Prediction with Uncertainty Quantification
25天前
已完结
Accurate 3D Structure Prediction of Small Cyclic Peptides Containing Non-Canonical Amino Acid Residues Using an All-Atom Diffusion Model with Stereogenic Implementation
26天前
已完结
Hydrogen Bond Basicity Prediction for Medicinal Chemistry Design
27天前
已完结
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design
28天前
已完结
Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment
28天前
已完结
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