Lv11
42 积分 2023-12-05 加入
RIPTACs expand anticancer target space
2小时前
已完结
Induced proximity pushes beyond protein degraders, as first RIPTAC moves into the clinic
2小时前
已完结
14 (PB002): Discovery of NKT3964: a first-in-class, highly potent and selective, orally bioavailable CDK2 PROTAC degrader for cancer therapy
2个月前
已完结
Scaffold Hopping-Based Structural Modification of Tranilast Led to the Identification of HNW005 as a Promising NLRP3 Inflammasome and URAT1 Dual Inhibitor for the Treatment of Gouty Arthritis
3个月前
已完结
Structural insight into apelin receptor-G protein stoichiometry
3个月前
已完结
Scaffold Hopping-Based Structural Modification of Tranilast Led to the Identification of HNW005 as a Promising NLRP3 Inflammasome and URAT1 Dual Inhibitor for the Treatment of Gouty Arthritis
3个月前
已完结
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
4个月前
已完结
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin
4个月前
已完结
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948
4个月前
已完结
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
4个月前
已完结
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