Lv3
300 积分 2024-12-11 加入
Development of a dual functional RNAi therapeutic, ARO-DIMER-PA, for mixed hyperlipidemia
14天前
已完结
Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
15天前
已完结
Unlocking biological barriers: nonclinical safety considerations for RNA-based complex biologics
28天前
已完结
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3 End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute2 PAZ Domain
1个月前
已完结
Presence of phosphodiester backbone, but not nucleobases, in the guide’s 3′ terminal region is necessary for RISC loading and target cleavage in vitro and in vivo
1个月前
已完结