Lv12
24 积分 2023-12-18 加入
Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor
21小时前
已完结
Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors
21小时前
已完结
Identification of a Human Whole Blood–Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo
1天前
已完结
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
1天前
已完结
Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists
1天前
已完结
Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation
1天前
已完结
Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors
1天前
已完结
Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors
1天前
已完结
Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders
1天前
已完结
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain
1天前
已完结
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