Lv71
5000 积分 2024-03-01 加入
Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations
27天前
已完结
Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy
1个月前
已完结
Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365
2个月前
已完结
Targeting Multiple KRAS Mutations with High-Affinity Macrocyclic Inhibitors: From Discovery to Preclinical Validation
2个月前
已完结
From KRAS G12D to Pan-KRAS Inhibitors─A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design
2个月前
已完结
Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer
4个月前
已完结
Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders
4个月前
已完结
Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC
5个月前
已完结
Targeting cancer with small molecule pan-KRAS degraders
5个月前
已完结
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
5个月前
已完结
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