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30 积分 2021-07-21 加入
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid
9小时前
求助中
Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors
6个月前
已完结
AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications
6个月前
已完结
Combined Blockade of Lipid Uptake and Synthesis by CD36 Inhibitor and SCD1 siRNA Is Beneficial for the Treatment of Refractory Prostate Cancer
6个月前
已关闭
A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H2O2-Triggered Targeted Protein Degradation in Cancer Therapy
6个月前
已完结
Targeted Protein Degradation: Current and Emerging Approaches for E3 Ligase Deconvolution
6个月前
已完结
Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression
6个月前
已完结
Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader
6个月前
已完结
Overview of AKR1C3: Inhibitor Achievements and Disease Insights
7个月前
已完结
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents
9个月前
已完结
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