Lv31
248 积分 2023-11-16 加入
Exposing Hidden Binding Pockets in Cereblon: His378 Conformational Dynamics Inform Novel Ligand Design
2小时前
已完结
A structural basis for amylin receptor phenotype
6天前
已完结
Identification of an allosteric site on the E3 ligase adapter cereblon
25天前
已完结
On Ternary Complex Stability in Protein Degradation: In Silico Molecular Glue Binding Affinity Calculations
1个月前
已完结
Terminal-Flip Monte Carlo: Accelerating the Convergence of Molecular Dynamics and Alchemical Free Energy Calculations
1个月前
已完结
Application of Weighted Interaction-Fingerprints for Rationalizing Neosubstrate Potency and Selectivity of Cereblon-Based Molecular Glues
1个月前
已完结
One-Step Regioselective Synthesis of N-1-Substituted Dihydrouracils: A Motif of Growing Popularity in the Targeted Protein Degradation Field
1个月前
已完结
Prospective Evaluation of Structure-Based Simulations Reveal Their Ability to Predict the Impact of Kinase Mutations on Inhibitor Binding
2个月前
已完结
Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads
2个月前
已完结
Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations
2个月前
已完结
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