Lv11
70 积分 2024-10-28 加入
New insights into the noncanonical inflammasome point to caspase-4 as a druggable target
5天前
已完结
Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
5天前
已完结
Discovery of Anthranilic Acid Derivatives as Antagonists of the Pro-Inflammatory Orphan G Protein-Coupled Receptor GPR17
22天前
已完结
Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target
23天前
已完结
Discovery and Development of NLRP3 Inhibitors Targeting the LRR Domain to Disrupt NLRP3-NEK7 Interaction for the Treatment of Rheumatoid Arthritis
1个月前
已完结
Reduction of NLRP3 inflammasome-mediated inflammation in a novel inducible NEK7 knockout mouse model
1个月前
已完结
Identification of an allosteric site on the E3 ligase adapter cereblon
1个月前
已完结
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
1个月前
已完结
NEK7-mediated activation of NLRP1 and NLRP3 inflammasomes in the progression of Gestational Diabetes Mellitus
1个月前
已完结
Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase
1个月前
已关闭
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