Lv68
2620 积分 2025-03-13 加入
The Discovery of TNG456: A Highly Potent, Selective, Brain-Penetrant MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers
6天前
已完结
Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470, an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluation
6天前
已完结
Early Process Development of a Heterobifunctional Protein Degrader
17天前
已完结
Design, Synthesis, and Identification of an Orally Bioavailable Small-Molecule HBsAg Production Inhibitor with High Hepatoselectivity and Reduced Neurotoxic Potential
17天前
已完结
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist
25天前
已完结
Discovery of FLT3-ITD Inhibitor Clifutinib: A Novel Biphenylacetylene Urea Derivative in Clinical Trials for the Treatment of Relapsed/Refractory FLT3-ITD+ Acute Myeloid Leukemia
1个月前
已完结
Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist
1个月前
已完结
Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer
1个月前
已完结
Discovery of a Potent RXRγ Degrader WCF-598 for the Treatment of Castration-Resistant Prostate Cancer
2个月前
已完结
Design, synthesis and evaluation of 1,2-dihydropyrido[2,3-d]pyrimidine-6‑carbonitrile derivatives as novel covalent inhibitors for the treatment of KRASG12C-mutant NSCLC
2个月前
已完结
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