Lv11
44 积分 2025-05-19 加入
Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs
1小时前
待确认
Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19
2小时前
已完结
A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
11天前
已完结
Structure-Guided Design of a Highly Selective PI3Kα Inhibitor Overcoming Metabolic Dysregulation with Potent Anti-breast Cancer Efficacy
24天前
已完结
A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo
26天前
已完结
Temporal and Spatial Characterization of CUL3KLHL20-Driven Targeted Degradation of BET Family BRD Proteins by the Macrocycle-Based Degrader BTR2004
26天前
已完结
Discovery of BRD9 Molecular Glue Degraders That Spare Cardiomyocytes
26天前
已完结
Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody
29天前
已完结
Induced proximity-based therapeutic modalities
1个月前
已完结
Combinatorial strategies to target RAS-driven cancers
1个月前
已完结
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