Lv4
416 积分 2025-02-25 加入
Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads
6天前
已完结
Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates
8天前
已完结
Chemical Modification of Linkers Provides Stable Linker–Payloads for the Generation of Antibody–Drug Conjugates
8天前
已完结
Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition
10天前
已完结
The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma
14天前
已完结
Structure-guided molecular glues
14天前
已完结
Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective
23天前
已完结
Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases
23天前
已完结
An open-source drug discovery platform enables ultra-large virtual screens
1个月前
已完结
Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway
3个月前
已完结
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