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592 积分 2024-11-04 加入
Misconceptions among medicinal chemists regarding ADME and PK optimization
8天前
已完结
Identification of an Orally Bioavailable Quinoline-Based Small-Molecule Tumor Necrosis Factor α (TNF-α) Inhibitor Featuring a Spirocyclic Scaffold
10天前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
10天前
已完结
Discovery of a selective CDK7 PROTAC against acute leukemia with low platelet toxicity
12天前
已完结
Chronic Myeloid Leukemia: A Review
25天前
已完结
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
25天前
已完结
The Dawn of Allosteric BCR-ABL1 Drugs: From a Phenotypic Screening Hit to an Approved Drug
25天前
已完结
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor
1个月前
已完结
NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease
1个月前
已完结
CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer
1个月前
已完结
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