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632 积分 2024-11-04 加入
Siegfried H. Reich et al. Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition
21小时前
已完结
he Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites
20天前
已完结
Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470, an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluatio
1个月前
已完结
NMR Structure of a Potent Small Molecule Inhibitor Bound to Human Keratinocyte Fatty Acid-Binding Protein
1个月前
已完结
Synthesis and Biological Evaluation of 2,4-Disubstituted 5-Aminothiazoles as Selective COX-2 Inhibitors
1个月前
已关闭
2-Aminopyridines as Potent and Selective Nav1.8 Inhibitors Exhibiting Efficacy in a Nonhuman Primate Pain ModelClick to copy article link
1个月前
已完结
Misconceptions among medicinal chemists regarding ADME and PK optimization
2个月前
已完结
Identification of an Orally Bioavailable Quinoline-Based Small-Molecule Tumor Necrosis Factor α (TNF-α) Inhibitor Featuring a Spirocyclic Scaffold
2个月前
已完结
Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers
2个月前
已完结
Discovery of a selective CDK7 PROTAC against acute leukemia with low platelet toxicity
2个月前
已完结
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