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88 积分 2024-06-18 加入
IKZF1 Regulates BRD4 Retention and Recruitement at Enhancer in Myeloma Cells: Role of BRD4 in IMiDs Resistance
1个月前
已关闭
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
1个月前
已完结
Discovery of Novel Alkynylbenzene Scaffold-Based PTPN2-Selective Degrader PD-305 with Exceptional Potency and In Vivo Efficacy
1个月前
已完结
Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia
1个月前
已完结
Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma
1个月前
已完结
Discovery of a selective CDK7 PROTAC against acute leukemia with low platelet toxicity
1个月前
已完结
Benzofuranyl-pyrazole as a Novel Scaffold for In Vitro and In Vivo Potent Anticancer Therapeutics That Directly Disrupt the ‘Undruggable’ MYC Oncogene and Potentiate Immune Checkpoint Blockage
1个月前
已完结
Harnessing the Deubiquitinase USP1 for Targeted Protein Stabilization
2个月前
已完结
Analysis of Protein Stability and Ligand Interactions by Thermal Shift Assay
3个月前
已完结
USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities
3个月前
已完结