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40 积分 2022-12-08 加入
X-ray crystallography study and optimization of novel benzothiophene analogs as potent selective estrogen receptor covalent antagonists (SERCAs) with improved potency and safety profiles
4天前
待确认
Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects
6天前
已完结
Natural isoflavone glabridin targets PI3Kγ as an adjuvant to increase the sensitivity of MDA-MB-231 to tamoxifen and DU145 to paclitaxel
1个月前
已完结
A novel feedback catalytic hairpin assembly strategy for sensitive mRNA imaging in living cells
2个月前
已完结
Design, synthesis, biological evaluation and molecular docking studies of novel 3-aryl-4-anilino-2 H -chromen-2-one derivatives targeting ERα as anti-breast cancer agents
2个月前
已完结
Target-Triggered Cascaded Self-Feedback DNAzyme Circuit Loaded in ZIF-8 for Highly Sensitive miRNA Imaging in Living Cells
3个月前
已完结
A DNA Tetrahedron Assembly-Based Nanoshell-Mediated Nanoflares for Intracellular MiRNA Imaging: Reducing False Positivity and Improving Reaction Kinetics and Efficiency
3个月前
已完结
Structure-based virtual screening, molecular simulation and free energy calculations of traditional Chinese medicine, ZINC database revealed potent inhibitors of estrogen-receptor α (ERα)
8个月前
已完结
Identifying the Active Ingredients of Climate Change Narratives: A Model of Temporal Perspective, Narrator Perspective, and Psychological Distance
11个月前
已完结
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists
1年前
已完结
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