DYK
Lv2
140 积分
2023-09-18 加入
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Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)
10天前
已完结
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Coupling of receptor conformation and ligand orientation determine graded activity
12天前
已完结
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Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility
13天前
已完结
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A simple one-step synthesis of N-substituted isoindolin-1-ones. Diastereofacially selective protonation of an intermediate isoindolinol
16天前
已完结
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Discovery of a Candidate Containing an (S)-3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia
1个月前
已完结
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Identification of Piperazinyl–Difluoro-indene Derivatives Containing Pyridyl Groups as Potent FGFR Inhibitors against FGFR Mutant Tumor: Design, Synthesis, and Biological Evaluation
1个月前
已完结
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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations
1个月前
已完结
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Synthesis of a model hapten with cyclohexanediol and .alpha.-methylene-.gamma.-butyrolactone groups, a synthetic analog of poison ivy and tulipalin allergens connected with a carbon chain
1个月前
已完结
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ChemInform Abstract: Synthesis of 2‐Alkyl‐2,3,6,7‐tetrahydrooxepins and 2‐Alkyl‐2,3,6,7‐tetrahydrooxocins from Allylsilanes
1个月前
已完结
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Synthesis of Mycobacterium tuberculosis Sulfolipid-3 Analogues and Total Synthesis of the Tetraacylated Trehaloglycolipid of Mycobacterium paraffinicum
1个月前
已完结